Isolated spinal cord contusion in rats induces chronic brain neuroinflammation, neurodegeneration, and cognitive impairment
نویسندگان
چکیده
منابع مشابه
O17: Inflammation in Brain and Spinal Cord
our goal in this paper is to describe and compare basic immunopathologic pattern of common demyelinating disorder, that is very important to choose the best treatment. The most common disorders are multiple sclerosis, neuromyelitis optica,Anti MOG associated disease,ADEM and autoimmune encephalitis. ADEM consists of ‘‘sleeves’’ of demyelination centered on small, engorge...
متن کاملFunctional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions
Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to r...
متن کاملA contusion model of severe spinal cord injury in rats.
The translational potential of novel treatments should be investigated in severe spinal cord injury (SCI) contusion models. A detailed methodology is described to obtain a consistent model of severe SCI. Use of a stereotactic frame and computer controlled impactor allows for creation of reproducible injury. Hypothermia and urinary tract infection pose significant challenges in the post-operativ...
متن کاملChronic administration of isocarbophos induces vascular cognitive impairment in rats
Vascular dementia, being the most severe form of vascular cognitive impairment (VCI), is caused by cerebrovascular disease. Whether organophosphorus causes VCI remains unknown. Isocarbophos (0.5 mg/kg per 2 days) was intragastrically administrated to rats for 16 weeks. The structure and function of cerebral arteries were assayed. The learning and memory were evaluated by serial tests of step-do...
متن کاملContusion of Spinal Cord Tissue
You might find this additional info useful... 24 times a year (twice monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD systems with techniques linking genes and pathways to physiology, from prokaryotes to eukaryotes. It is published publishes results of a wide variety of studies from human and from informative model Physiological Genomics
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2014
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.29420